CGH2466 (dihydrochloride)

CGH 2466 dihydrochloride is an orally active adenosine A1, A2B and A3 receptor antagonist with the IC50 values of 19 nM, 21 nM, and 80 nM respectively. CGH 2466 dihydrochloride inhibits p38 MAPK (IC50 = 187~ 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM) . CGH 2466 dihydrochloride displays potent anti-inflammatory effects both in vitro and in vivo, and can be used for research on asthma and chronic obstructive pulmonary disease (COPD) [1].

Product Specifications

CAS Number

[1177618-54-0]

UNSPSC

12352005

Target

Adenosine Receptor; p38 MAPK; Phosphodiesterase (PDE)

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

NC1=NC(C2=CC=C(Cl)C(Cl)=C2)=C(C3=CC=NC=C3)S1.Cl.Cl

Molecular Formula

C14H11Cl4N3S

Molecular Weight

395.13

References & Citations

[1]Trifilieff A, et al. CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities. Br J Pharmacol. 2005;144 (7) :1002-1010.