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GR 113808 (Standard)

GR 113808 (Standard) is the analytical standard of GR 113808. This product is intended for research and analytical applications. GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8) . GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1].

Product Specifications

CAS Number

144625-51-4

UNSPSC

12352005

Target

5-HT Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(C1=CN(C)C2=C1C=CC=C2)OCC3CCN(CCNS(=O)(C)=O)CC3

Molecular Formula

C19H27N3O4S

Molecular Weight

393.50

References & Citations

[1]Gale JD, et al. GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.Br J Pharmacol. 1994 Jan;111 (1) :332-8.|[2]Spohn SN, et al.Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.Gastroenterology. 2016 Nov;151 (5) :933-944.e3.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

5-HT1 Receptor;5-HT2 Receptor

Available Sizes

Frequently Asked Questions

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