EMD 386088 (free base)

EMD386088 free base is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 free base induces cell death. EMD386088 free base regulates the activity of ERK1/2. EMD386088 free base has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3][4].

Product Specifications

CAS Number

[54635-62-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

CC(N1)=C(C2=CCNCC2)C3=C1C=CC(Cl)=C3

Molecular Formula

C14H15ClN2

Molecular Weight

246.74

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yun HM, et al. 5-HT6 receptor ligands, EMD386088 and SB258585, differentially regulate 5-HT6 receptor-independent events. Toxicol In Vitro. 2011 Dec;25 (8) :2035-40.|[2]Meneses A, et al. The effects of the 5-HT (6) receptor agonist EMD and the 5-HT (7) receptor agonist AS19 on memory formation. Behav Brain Res. 2008 Dec 16;195 (1) :112-9.|[3]Amodeo DA, et al. 5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory. Behav Brain Res. 2018 Sep 3;349:8-15.|[4]Mattsson C, et al. 2-Alkyl-3- (1,2,3,6-tetrahydropyridin-4-yl) -1H-indoles as novel 5-HT6 receptor agonists. Bioorg Med Chem Lett. 2005 Oct 1;15 (19) :4230-4.