SB 202190 (hydrochloride) (Standard)

SB 202190 (hydrochloride) (Standard) is the analytical standard of SB 202190 (hydrochloride) . This product is intended for research and analytical applications. SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3].

Product Specifications

CAS Number

[350228-36-3]

UNSPSC

12352005

Target

Apoptosis; Autophagy; Organoid; p38 MAPK; Reference Standards

Related Pathways

Apoptosis; Autophagy; MAPK/ERK Pathway; Others; Stem Cell/Wnt

Field of Research

Cancer; Neurological Disease

Smiles

OC1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1.[H]Cl

Molecular Formula

C20H15ClFN3O

Molecular Weight

367.80

References & Citations

[1]Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351 (Pt 1) :95-105.|[2]Yang S, et al. Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia. Biomed Res Int. 2013;2013:215798.