Gosogliptin (hydrochloride)

Gosogliptin hydrochloride is the hydrochloride of Gosogliptin (HY-10287) . Gosogliptin (PF-00734200) is a potent, orally active, selective, and competitive inhibitor of DPP-IV, the enzyme mainly responsible for the degradation of the incretin peptides GLP-1 and glucose-dependent insulinotropic polypeptide. Gosogliptin demonstrates rapid and reversible inhibition of plasma DPP-4 activity. Gosogliptin stimulates insulin secretion and improves glucose tolerance[1][2].

Product Specifications

CAS Number

[869490-47-1]

UNSPSC

12352005

Target

Dipeptidyl Peptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C([C@H](C1)NC[C@H]1N2CCN(CC2)C3=NC=CC=N3)N4CC(CC4)(F)F.Cl.Cl

Molecular Formula

C17H26Cl2F2N6O

Molecular Weight

439.33

References & Citations

[1]Dai H, et al. The pharmacokinetics of PF-734200, a DPP-IV inhibitor, in subjects with renal insufficiency. Br J Clin Pharmacol. 2011 Jul;72 (1) :85-91. |[2]Sharma R, et al. Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl) ((2S,4S) -4- (4- (pyrimidin-2-yl) piperazin-1-yl) pyrrolidin-2-yl) methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human. Drug Metab Dispos. 2012 Nov;40 (11) :2143-61.