Cis-NVP-ADW742
Cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742. NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells[1][2].
Product Specifications
CAS Number
475489-15-7
Product Name Alternative
Cis-ADW742; cis-GSK 552602A; cis-ADW
UNSPSC
12352005
Target
Apoptosis; IGF-1R; Insulin Receptor
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
NC1=C2C(N([C@H]3C[C@@H](CN4CCCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Molecular Formula
C28H31N5O
Molecular Weight
453.58
References & Citations
[1]Marvin C. Gershengorn, et al. Combination therapy of tshr antagonist and igfr inhibitor. Patent. WO2016064716 A1
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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