Cis-NVP-ADW742

Cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742 (HY-10252) . NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells[1][2].

Product Specifications

CAS Number

[475489-15-7]

Product Name Alternative

Cis-ADW742; cis-GSK 552602A; cis-ADW

UNSPSC

12352005

Target

Apoptosis; IGF-1R; Insulin Receptor

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

NC1=C2C(N([C@H]3C[C@@H](CN4CCCC4)C3)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1

Molecular Formula

C28H31N5O

Molecular Weight

453.58

References & Citations

[1]Marvin C. Gershengorn, et al. Combination therapy of tshr antagonist and igfr inhibitor. Patent. WO2016064716 A1

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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