Mericitabine (Standard)

Mericitabine (Standard) is the analytical standard of Mericitabine. This product is intended for research and analytical applications. Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

Product Specifications

CAS Number

[940908-79-2]

Product Name Alternative

RG 7128 (Standard) ; R-7128 (Standard) ; PSI 6130 diisobutyrate (Standard)

UNSPSC

12352005

Target

HCV; Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

O=C1N=C(C=CN1[C@@H]([C@@](C)([C@@H]2OC(C(C)C)=O)F)O[C@@H]2COC(C(C)C)=O)N

Molecular Formula

C18H26FN3O6

Molecular Weight

399.41

References & Citations

[1]Le Pogam S, et al. Characterization of HCV quasispecies dynamics upon short term dual-therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir. Antimicrob Agents Chemother. 2012 Nov;56 (11) :5494-5|[2]Soriano V, et al. Directly acting antivirals against hepatitis C virus. J Antimicrob Chemother. 2011 Aug;66 (8) :1673-86|[3]Guedj J, et al. Hepatitis C viral kinetics with the nucleoside polymerase inhibitor mericitabine (RG7128) . Hepatology. 2012 Apr;55 (4) :1030-7.