Luminespib (Standard)
Luminespib (Standard) is the analytical standard of Luminespib. This product is intended for research and analytical applications. Luminespib (VER-52296) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively[1].
Product Specifications
CAS Number
747412-49-3
Product Name Alternative
VER-52296 (Standard) ; AUY922 (Standard) ; NVP-AUY922 (Standard)
UNSPSC
12352005
Target
Apoptosis; Autophagy; HSP; Reference Standards
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC
Molecular Formula
C26H31N3O5
Molecular Weight
465.54
References & Citations
[1]Eccles, Suzanne A., et al. NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis. Cancer Research (2008), 68 (8), 2850-2860.|[2]Best OG, et al. Heat shock protein-90 inhibitor, NVP-AUY922, is effective in combination with NSC 118218 against chronic lymphocytic leukemia cells cultured on CD40L-stromal layer and inhibits their activated/proliferative phenotype. Leuk Lymphoma. 2012 Jul 9.|[3]Moser C, et al. Stoeltzing O.Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer. Anticancer Res. 2012 Jul;32 (7) :2551-61.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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