Dovitinib (lactate) (Standard)

Dovitinib (lactate) (Standard) is the analytical standard of Dovitinib (lactate) . This product is intended for research and analytical applications. Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].

Product Specifications

CAS Number

[692737-80-7]

Product Name Alternative

CHIR-258 lactate (Standard) ; TKI-258 lactate (Standard)

UNSPSC

12352005

Target

C-Kit; FGFR; FLT3; PDGFR; Reference Standards; VEGFR

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O

Molecular Formula

C24H27FN6O4

Molecular Weight

482.51

References & Citations

[1]Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t (4;14) multiple myeloma. Blood. 2005, 105 (7), 2941-2948.|[2]Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56 (3), 595-601.