Dovitinib (lactate) (Standard)
Dovitinib (lactate) (Standard) is the analytical standard of Dovitinib (lactate) . This product is intended for research and analytical applications. Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively[1].
Product Specifications
CAS Number
692737-80-7
Product Name Alternative
CHIR-258 lactate (Standard) ; TKI-258 lactate (Standard)
UNSPSC
12352005
Target
C-Kit; FGFR; FLT3; PDGFR; Reference Standards; VEGFR
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N1)C(C(NC2=C3)=NC2=CC=C3N4CCN(C)CC4)=C(N)C5=C1C=CC=C5F.O=C(O)C(C)O
Molecular Formula
C24H27FN6O4
Molecular Weight
482.51
References & Citations
[1]Trudel S, et al. CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t (4;14) multiple myeloma. Blood. 2005, 105 (7), 2941-2948.|[2]Huynh H, et al. Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma. J Hepatol. 2012, 56 (3), 595-601.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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