Tyrphostin 25 (Standard)
Tyrphostin 25 (Standard) (AG82 (Standard) ) is the analytical standard of Tyrphostin 25. This product is intended for research and analytical applications. Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM[1][2][3].
Product Specifications
CAS Number
118409-58-8
Product Name Alternative
AG82 (Standard) ; Tyrphostin A 25 (Standard) ; Tyrphostin AG 82 (Standard) ; RG-50875 (Standard)
UNSPSC
12352005
Target
EGFR; GPR35 ; Reference Standards
Related Pathways
GPCR/G Protein; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Smiles
N#C/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1
Molecular Formula
C10H6N2O3
Molecular Weight
202.17
References & Citations
[1]Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127 (3) :859-66. |[2]Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585 (12) :1957-62.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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