Tyrphostin 25 (Standard)

Tyrphostin 25 (Standard) (AG82 (Standard) ) is the analytical standard of Tyrphostin 25 (HY-101958) . This product is intended for research and analytical applications. Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM[1][2][3].

Product Specifications

CAS Number

[118409-58-8]

Product Name Alternative

AG82 (Standard) ; Tyrphostin A 25 (Standard) ; Tyrphostin AG 82 (Standard) ; RG-50875 (Standard)

UNSPSC

12352005

Target

EGFR; GPR35 ; Reference Standards

Related Pathways

GPCR/G Protein; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Inflammation/Immunology

Smiles

N#C/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1

Molecular Formula

C10H6N2O3

Molecular Weight

202.17

References & Citations

[1]Klemke RL, et al. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. J Cell Biol. 1994 Nov;127 (3) :859-66. |[2]Deng H, et al. Tyrphostin analogs are GPR35 agonists. FEBS Lett. 2011 Jun 23;585 (12) :1957-62.