AG 1295 (Standard)
AG 1295 (Standard) is the analytical standard of AG 1295. This product is intended for research and analytical applications. AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG1295 abolishes autophosphorylation of the PDGFR whereas not affects the autophosphorylation of the EGF receptor[1][2][3][4].
Product Specifications
CAS Number
71897-07-9
UNSPSC
12352005
Target
PDGFR; Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cardiovascular Disease
Smiles
CC1=C(C)C=C2N=CC(C3=CC=CC=C3)=NC2=C1
Molecular Formula
C16H14N2
Molecular Weight
234.30
References & Citations
[1]Zheng Y, et al. Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Jpn J Ophthalmol. 2003 Mar-Apr;47 (2) :158-65.|[2]Inhibition of aortic allograft vasculopathy by local delivery of platelet-derived growth factor receptor tyrosine-kinase blocker AG-1295. Transplantation. 2002 Nov 15;74 (9) :1335-41.|[3]Kovalenko M, et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res. 1994 Dec 1;54 (23) :6106-14.|[4]Ludewig D, et al. PDGF receptor kinase blocker AG1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction. Cell Tissue Res. 2000 Jan;299 (1) :97-103.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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