NOD1/2 antagonist-2

NOD1/2 antagonist-2 (Compound 26BH) is a dual NOD1/NOD2 antagonist (IC50s: 2.36 μM and 4.16 μM for NOD1 and NOD2, respectively) . NOD1/2 antagonist-2 inhibits both NF-κB and MAPK inflammatory signaling, thereby sensitizing Paclitaxel (HY-B0015) to suppress Lewis lung carcinoma growth[1].

Product Specifications

CAS Number

[2101736-25-6]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

O=C(C1=CC(OC2=CC=CC(N(C)C)=C2)=C(NC(COCC3=CC=CC=C3)=O)C=C1N4)N[C@H](CCC(NCCC)=O)C4=O

Molecular Formula

C32H37N5O6

Molecular Weight

587.67

References & Citations

[1]Wang S, et al. Discovery of 1,4-Benzodiazepine-2,5-dione (BZD) Derivatives as Dual Nucleotide Binding Oligomerization Domain Containing 1/2 (NOD1/NOD2) Antagonists Sensitizing Paclitaxel (PTX) To Suppress Lewis Lung Carcinoma (LLC) Growth in Vivo. J Med Chem. 2017 Jun 22;60 (12) :5162-5192.