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EIPA (hydrochloride) (Standard)

EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride) . This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3) . EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][5].

Product Specifications

CAS Number

1345839-28-2

Product Name Alternative

L593754 (hydrochloride) (Standard) ; MH 12-43 (hydrochloride) (Standard) ; Ethylisopropylamiloride (hydrochloride) (Standard)

UNSPSC

12352005

Target

Autophagy; COX; Na+/H+ Exchanger (NHE) ; Prostaglandin Receptor; Reference Standards; TRP Channel

Related Pathways

Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=NC(Cl)=C(N(CC)C(C)C)N=C1N)NC(N)=N.Cl

Molecular Formula

C11H19Cl2N7O

Molecular Weight

336.22

References & Citations

[1]Dai XQ, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol. 2007 Dec;72 (6) :1576-85.|[2]Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42 (6) :2418-2429.|[3]Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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