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Dasatinib (GMP Like)

Dasatinib (GMP Like) (BMS-354825 (GMP Like) ) is Dasatinib produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of. Dasatinib also induces apoptosis and autophagy.

Product Specifications

CAS Number

302962-49-8

Product Name Alternative

BMS-354825 (GMP Like)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Bcr-Abl; Src

Related Pathways

Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C

Molecular Formula

C22H26ClN7O2S

Molecular Weight

488.01

References & Citations

[1]Lombardo LJ, et al. Discovery of N- (2-chloro-6-methyl- phenyl) -2- (6- (4- (2-hydroxyethyl) - piperazin-1-yl) -2-methylpyrimidin-4- ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47 (27) :6658-61.

Shipping Conditions

Room temperature

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Frequently Asked Questions

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