Dasatinib (hydrochloride) (Standard)

Dasatinib (hydrochloride) (Standard) is the analytical standard of Dasatinib (hydrochloride) . This product is intended for research and analytical applications. Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of [1]. Dasatinib hydrochloride also induces apoptosis and autophagy.

Product Specifications

CAS Number

[854001-07-3]

Product Name Alternative

BMS-354825 (hydrochloride) (Standard)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Bcr-Abl; Reference Standards; Src

Related Pathways

Apoptosis; Autophagy; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C.[H]Cl

Molecular Formula

C22H27Cl2N7O2S

Molecular Weight

524.47

References & Citations

[1]Lombardo LJ, et al. Discovery of N- (2-chloro-6-methyl- phenyl) -2- (6- (4- (2-hydroxyethyl) - piperazin-1-yl) -2-methylpyrimidin-4- ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem. 2004 Dec 30;47 (27) :6658-61.