Ziritaxestat (Standard)
Ziritaxestat (Standard) is the analytical standard of Ziritaxestat. This product is intended for research and analytical applications. Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC50 of 131 nM and a Ki of 15 nM[1].
Product Specifications
CAS Number
1628260-79-6
Product Name Alternative
GLPG1690 (Standard)
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology
Smiles
N#CC1=C(C2=CC=C(F)C=C2)N=C(N(C3=C(CC)N=C4C(C)=CC(N5CCN(CC(N6CC(O)C6)=O)CC5)=CN43)C)S1
Molecular Formula
C30H33FN8O2S
Molecular Weight
588.70
References & Citations
[1]Desroy N, et al. Discovery of 2-[[2-Ethyl-6-[4-[2- (3-hydroxyazetidin-1-yl) -2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4- (4-fluorophenyl) thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2017 May 11;60 (9) :3580-3590.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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