PSI-6130 (Standard)
PSI-6130 (Standard) is the analytical standard of PSI-6130 (HY-10165) . This product is intended for research and analytical applications. PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase, and inhibits HCV replication with a mean IC50 of 0.6 μM.
Product Specifications
CAS Number
[817204-33-4]
Target
HCV; Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
O=C1N=C(C=CN1[C@@H]([C@@](C)([C@@H]2O)F)O[C@@H]2CO)N
Molecular Formula
C10H14FN3O4
Molecular Weight
259.24
References & Citations
[1]Ali S, et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Antimicrob Agents Chemother. 2008 Dec;52 (12) :4356-69.|[2]Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282 (41) :29812-20. Epub 2007 Aug 13.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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