Intoplicine (dimesylate) (Standard)
Intoplicine (dimesylate) (Standard) is the analytical standard of Intoplicine (dimesylate). This product is intended for research and analytical applications. Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA[1][2].
Product Specifications
CAS Number
133711-99-6
Target
Reference Standards; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
OC1=CC=C2C3=C(NC4=C3C(NCCCN(C)C)=NC=C4C)C=CC2=C1.CS(O)(=O)=O.CS(O)(=O)=O
Molecular Formula
C23H32N4O7S2
Molecular Weight
540.65
References & Citations
[1]Riou JF, et al. Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities. Cancer Res. 1993;53 (24) :5987-5993.|[2]Eckardt JR, et al. Activity of intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994;86 (1) :30-33.|[3]Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11 (4) :263-277.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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