Intoplicine (dimesylate) (Standard)
Intoplicine (dimesylate) (Standard) is the analytical standard of Intoplicine (dimesylate) (HY-101647A) . This product is intended for research and analytical applications. Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA[1][2].
Product Specifications
CAS Number
[133711-99-6]
Target
Reference Standards; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
OC1=CC=C2C3=C(NC4=C3C(NCCCN(C)C)=NC=C4C)C=CC2=C1.CS(O)(=O)=O.CS(O)(=O)=O
Molecular Formula
C23H32N4O7S2
Molecular Weight
540.65
References & Citations
[1]Riou JF, et al. Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities. Cancer Res. 1993;53 (24) :5987-5993.|[2]Eckardt JR, et al. Activity of intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994;86 (1) :30-33.|[3]Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11 (4) :263-277.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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