Tozasertib (Standard)
Tozasertib (Standard) is the analytical standard of Tozasertib (HY-10161) . This product is intended for research and analytical applications. Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively.
Product Specifications
CAS Number
[639089-54-6]
Target
Aurora Kinase; Autophagy; Reference Standards
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
CC1=CC(NC2=NC(SC3=CC=C(C=C3)NC(C4CC4)=O)=NC(N5CCN(CC5)C)=C2)=NN1
Molecular Formula
C23H28N8OS
Molecular Weight
464.59
References & Citations
[1]Harrington EA, et al. VX-680, a potent and selective smallmolecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med. 2004; 10:262-7.|[2]Salah E, et al. Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.J Med Chem. 2011 Apr 14;54 (7) :2359-67. Epub 2011 Mar 18.|[3]Arlot-Bonnemains Y, et al. Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines. Endocr Relat Cancer. 2008 Jun;15 (2) :559-68
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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