Gefapixant (citrate) (Standard)
Gefapixant (citrate) (Standard) is the analytical standard of Gefapixant (citrate). This product is intended for research and analytical applications. Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis[1][2][3].
Product Specifications
CAS Number
2310299-91-1
Target
P2X Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(CC(C(O)=O)(CC(O)=O)O)O.O=S(N)(C1=C(OC)C=C(C(C)C)C(OC2=CN=C(N)N=C2N)=C1)=O
Molecular Formula
C20H27N5O11S
Molecular Weight
545.52
References & Citations
[1]Anthony P. Ford, et al. The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders. Front Cell Neurosci. 2013; 7: 267.|[2]Ford AP, In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. Purinergic Signal. 2012 Feb;8 (Suppl 1) :3-26.|[3]Martin Nguyen A, et al. Validation of a visual analog scale for assessing cough severity in patients with chronic cough. Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211049743.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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