BMS-986158 (Standard)
BMS-986158 (Standard) is the analytical standard of BMS-986158. This product is intended for research and analytical applications. BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively[1].
Product Specifications
CAS Number
1800340-40-2
Target
Epigenetic Reader Domain; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
OC(C)(C)C1=CC=C2C(N([C@H](C3=CC=CC=C3)C4CCOCC4)C5=C2N=CC(C6=C(C)N=NN6C)=C5)=C1
Molecular Formula
C30H33N5O2
Molecular Weight
495.62
References & Citations
[1]Yin M, et al. Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction. Nat Commun. 2020 Apr 14;11 (1) :1833.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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