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BMS-986158 (Standard)

BMS-986158 (Standard) is the analytical standard of BMS-986158 (HY-101567) . This product is intended for research and analytical applications. BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively[1].

Product Specifications

CAS Number

[1800340-40-2]

Target

Epigenetic Reader Domain; Reference Standards

Related Pathways

Epigenetics; Others

Field of Research

Cancer

Smiles

OC(C)(C)C1=CC=C2C(N([C@H](C3=CC=CC=C3)C4CCOCC4)C5=C2N=CC(C6=C(C)N=NN6C)=C5)=C1

Molecular Formula

C30H33N5O2

Molecular Weight

495.62

References & Citations

[1]Yin M, et al. Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction. Nat Commun. 2020 Apr 14;11 (1) :1833.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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