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AZD-5991 (Standard)

AZD-5991 (Standard) is the analytical standard of AZD-5991. This product is intended for research and analytical applications. AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay[1].

Product Specifications

CAS Number

2143061-81-6

Target

Bcl-2 Family; Reference Standards

Related Pathways

Apoptosis; Others

Field of Research

Cancer

Smiles

O=C(O)C1=C(CCCOC2=C(C=CC=C3)C3=CC4=C2)C5=C(N1C)C(C6=C(C)N(C)N=C6CSCC7=NN(C)C(CS4)=C7)=C(Cl)C=C5

Molecular Formula

C35H34ClN5O3S2

Molecular Weight

672.26

References & Citations

[1]Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9 (1) :5341.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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