EIF4A3-IN-1 (Standard)
EIF4A3-IN-1 (Standard) is the analytical standard of eIF4A3-IN-1. This product is intended for research and analytical applications. eIF4A3-IN-1 is a selective eIF4A3 inhibitor (IC50: 0.26 μM; Kd: 0.043 μM) with cellular nonsense-mediated RNA decay (NMD) inhibitory activity. eIF4A3-IN-1 can specifically bind to the non-ATP binding site of eIF4A3. eIF4A3-IN-1 has anti-tumor and analgesic activities[1][2][3].
Product Specifications
CAS Number
2095486-67-0
Target
Eukaryotic Initiation Factor (eIF) ; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer; Neurological Disease
Smiles
ClC(C=C1)=CC=C1[C@@H]2N(C(C3=CC=C(Br)C=C3)=O)CCN(C(C4=C(C)N(C5=CC=CC(C#N)=C5)N=C4)=O)C2
Molecular Formula
C29H23BrClN5O2
Molecular Weight
588.88
References & Citations
[1]Ito M, et al. Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem. 2017 Apr 27;60 (8) :3335-3351.|[2]López-Cánovas JL, et al. Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing. Clin Transl Med. 2022 Nov;12 (11) :e1102.|[3]Hsieh MC, et al. Phosphorylated Upstream Frameshift 1-dependent Nonsense-mediated μ-Opioid Receptor mRNA Decay in the Spinal Cord Contributes to the Development of Neuropathic Allodynia-like Behavior in Rats. Anesthesiology. 2023 Jun 1;138 (6) :634-655.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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