TTT-28 (Standard)

TTT-28 (Standard) is the analytical standard of TTT-28 (HY-101511) . This product is intended for research and analytical applications. TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1) -mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1[1].

Product Specifications

CAS Number

[1609138-51-3]

Target

P-glycoprotein; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cancer

Smiles

O=C(N[C@@H](C(C)C)C1=NC(C(NC2=CC=CC=C2C(C3=CC=CC=C3)=O)=O)=CS1)C4=CC(OC)=C(OC)C(OC)=C4

Molecular Formula

C31H31N3O6S

Molecular Weight

573.66

References & Citations

[1]Wang YJ, et al. Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Sci Rep. 2017 Feb 9;7:42106.