TTT-28 (Standard)
TTT-28 (Standard) is the analytical standard of TTT-28. This product is intended for research and analytical applications. TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1) -mediated multidrug resistance (MDR) by selectively blocking the efflux function of ABCB1[1].
Product Specifications
CAS Number
1609138-51-3
Target
P-glycoprotein; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Smiles
O=C(N[C@@H](C(C)C)C1=NC(C(NC2=CC=CC=C2C(C3=CC=CC=C3)=O)=O)=CS1)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C31H31N3O6S
Molecular Weight
573.66
References & Citations
[1]Wang YJ, et al. Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1. Sci Rep. 2017 Feb 9;7:42106.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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