Temuterkib (Standard)
Temuterkib (Standard) is the analytical standard of Temuterkib. This product is intended for research and analytical applications. Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.
Product Specifications
CAS Number
1951483-29-6
Target
ERK; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5
Molecular Formula
C22H27N7O2S
Molecular Weight
453.56
References & Citations
[1]Shripad V. Bhagwat, et al. Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations. Cancer Research. July 2017.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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