Temuterkib (Standard)

Temuterkib (Standard) is the analytical standard of Temuterkib (HY-101494) . This product is intended for research and analytical applications. Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

Product Specifications

CAS Number

[1951483-29-6]

Target

ERK; Reference Standards

Related Pathways

MAPK/ERK Pathway; Others; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5

Molecular Formula

C22H27N7O2S

Molecular Weight

453.56

References & Citations

[1]Shripad V. Bhagwat, et al. Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations. Cancer Research. July 2017.