NE-100 (hydrochloride) (Standard)
NE-100 hydrochloride (Standard) is the analytical standard of NE-100 hydrochloride. This product is intended for research and analytical applications. NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases[1][2].
Product Specifications
CAS Number
149409-57-4
UNSPSC
12352005
Target
ATF6; Reference Standards; Sigma Receptor
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.[H]Cl
Molecular Formula
C23H34ClNO2
Molecular Weight
391.97
References & Citations
[1]Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434 (4) :904-9.|[2]Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53 (18) :PL285-90.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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