NE-100 (hydrochloride) (Standard)

NE-100 hydrochloride (Standard) is the analytical standard of NE-100 hydrochloride (HY-101484A) . This product is intended for research and analytical applications. NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases[1][2].

Product Specifications

CAS Number

[149409-57-4]

UNSPSC

12352005

Target

ATF6; Reference Standards; Sigma Receptor

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.[H]Cl

Molecular Formula

C23H34ClNO2

Molecular Weight

391.97

References & Citations

[1]Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434 (4) :904-9.|[2]Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53 (18) :PL285-90.