(R) -Zanubrutinib (Standard)

(R) -Zanubrutinib (Standard) is the analytical standard of (R) -Zanubrutinib (HY-101474B) . This product is intended for research and analytical applications. (R) -Zanubrutinib is the R enantiomer of Zanubrutinib (HY-101474A) . (R) -Zanubrutinib inhibits Bruton's tyrosine kinase (Btk) with an IC50 of 11 nM.

Product Specifications

CAS Number

[1691249-44-1]

Target

Btk; Reference Standards

Related Pathways

Others; Protein Tyrosine Kinase/RTK

Field of Research

Others

Smiles

NC(C1=C2N(N=C1C3=CC=C(OC4=CC=CC=C4)C=C3)[C@@H](C5CCN(C(C=C)=O)CC5)CCN2)=O

Molecular Formula

C27H29N5O3

Molecular Weight

471.55

References & Citations

[1]Wu J, et al. Acalabrutinib (ACP-196) : a selective second-generation BTK inhibitor. J Hematol Oncol. 2016 Mar 9;9:21.|[2]Wu J, et al. Second-generation inhibitors of Bruton tyrosine kinase. J Hematol Oncol. 2016 Sep 2;9 (1) :80.