Tz-Thalidomide (Standard)
Tz-Thalidomide (Standard) is the analytical standard of Tz-Thalidomide (HY-101460) . This product is intended for research and analytical applications. Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase) . Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2) . Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups[1].
Product Specifications
CAS Number
[2087490-42-2]
Target
Epigenetic Reader Domain; Molecular Glues; PROTACs; Reference Standards
Related Pathways
Epigenetics; Others; PROTAC
Field of Research
Cancer
Smiles
O=C(CCCCCOC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1)NCC(C=C4)=CC=C4C5=NN=C(C)N=N5
Molecular Formula
C29H29N7O6
Molecular Weight
571.58
References & Citations
[1]Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2 (12) :927-934.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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