Ceefourin 1 (Standard)
Ceefourin 1 (Standard) is the analytical standard of Ceefourin 1. This product is intended for research and analytical applications. Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma[1][2].
Product Specifications
CAS Number
315702-40-0
Target
P-glycoprotein; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Smiles
S=C1NN=C(CSC2=NC3=CC=CC=C3S2)N1C
Molecular Formula
C11H10N4S3
Molecular Weight
294.42
References & Citations
[1]Leanna Cheung, et al. High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4) . Biochem Pharmacol. 2014 Sep 1;91 (1) :97-108.|[2]Tony Huynh, et al. CCI52 sensitizes tumors to 6-mercaptopurine and inhibits MYCN-amplified tumor growth. Biochem Pharmacol. 2020 Feb;172:113770.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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