Sematilide (hydrochloride) (Standard)
Sematilide (hydrochloride) (Standard) is the analytical standard of Sematilide (hydrochloride) . This product is intended for research and analytical applications. Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM) . Sematilide is a class III antiarrhythmic agent[1].
Product Specifications
CAS Number
101526-62-9
Product Name Alternative
CK-1752 (hydrochloride) (Standard)
UNSPSC
12352005
Target
Potassium Channel; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1.Cl
Molecular Formula
C14H24ClN3O3S
Molecular Weight
349.88
References & Citations
[1]Ishii Y, et al. Effects of Sematilide, a novel class III antiarrhythmic agent, on membrane currents in rabbit atrial myocytes. Eur J Pharmacol. 1997 Jul 23;331 (2-3) :295-302.|[2]Stanley S. Greenberg, et al. Pharmacology of Sematilide, a non-quaternary class III antiarrhythmic agent.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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