LY-2434074

LY-2434074 is a selective β-secretase (BACE) inhibitor with an IC50 amyloid-β (Aβ40 and Aβ42) production. LY-2434074 can be used for the research of neurological disease, such as Alzheimer's disease[1].

Product Specifications

CAS Number

[883446-27-3]

UNSPSC

12352005

Target

Amyloid-β; Beta-secretase

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O[C@H]([C@]1([H])N[C@H]([C@@H](OC1)OCC(C)(C)C)C)[C@@H](NC(C)=O)CC2=CC(F)=CC(F)=C2.Cl

Molecular Formula

C21H33ClF2N2O4

Molecular Weight

450.95

References & Citations

[1]Timothy Barrett Durham, et al. 3- (2-acylamino-1-hydroxyethyl) - morpholine derivatives and their use as bace inhibitors. WO2006034093A2. 2006-03-30