GAL-021 (Standard)

GAL-021 (Standard) is the analytical standard of GAL-021 (HY-101422) . This product is intended for research and analytical applications. GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates[1][2].

Product Specifications

CAS Number

[1380341-99-0]

Target

Potassium Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Inflammation/Immunology

Smiles

CCCNC1=NC(N(OC)C)=NC(NCCC)=N1

Molecular Formula

C11H22N6O

Molecular Weight

254.33

References & Citations

[1]Golder FJ, et al. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Anesthesiology. 2015 Nov;123 (5) :1093-104.|[2]J F McLeod, et al. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014 Nov;113 (5) :875-83.