JNJ-47965567 (Standard)
JNJ-47965567 (Standard) is the analytical standard of JNJ-47965567 (HY-101418) . This product is intended for research and analytical applications. JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology[1].
Product Specifications
CAS Number
[1428327-31-4]
Target
P2X Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Smiles
O=C(C1=CC=CN=C1SC2=CC=CC=C2)NCC3(N4CCN(C5=CC=CC=C5)CC4)CCOCC3
Molecular Formula
C28H32N4O2S
Molecular Weight
488.64
References & Citations
[1]Bhattacharya A, et al. Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br J Pharmacol. 2013 Oct;170 (3) :624-40.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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