W146 (Standard)
W146 (Standard) is the analytical standard of W146. This product is intended for research and analytical applications. W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.
Product Specifications
CAS Number
909725-61-7
Target
Apoptosis; LPL Receptor; Reference Standards
Related Pathways
Apoptosis; GPCR/G Protein; Others
Field of Research
Cancer; Metabolic Disease
Smiles
O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O
Molecular Formula
C16H27N2O4P
Molecular Weight
342.37
References & Citations
[1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.|[3]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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