(R) -Niguldipine

(R) -Niguldipine, a R-epimer of Niguldipine (HY-101390B), is a calcium channel antagonist. (R) -Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R) -Niguldipine can inhibit U-46619 (HY-108566) -induced coronary artery contraction in guinea pig Langendorff hearts (pID50 of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55) . (R) -Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias[1].

Product Specifications

CAS Number

[120054-86-6]

UNSPSC

12352005

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Cardiovascular Disease

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@H]1C2=CC([N+]([O-])=O)=CC=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3

Molecular Formula

C36H39N3O6

Molecular Weight

609.71

References & Citations

[1]Eltze M, et al. Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists. Chirality. 1990;2 (4) :233-40.