Ro 10-5824
Ro 10-5824 is a potent and selective D4R partial agonist with a Ki of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice[1][2].
Product Specifications
CAS Number
[189744-46-5]
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
N=1C=C(C(=NC1C)N)CN2CC=C(C=3C=CC=CC3)CC2
Molecular Formula
C17H20N4
Molecular Weight
280.38
References & Citations
[1]Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44 (4) :473-81.|[2]Cummings DF, et al. Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548. J Pharmacol Exp Ther. 2010 Jun;333 (3) :682-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor
Curated Selection
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