QX-222 (chloride) (Standard)
QX-222 (chloride) (Standard) is the analytical standard of QX-222 (chloride) (HY-101362) . This product is intended for research and analytical applications. QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker[1][2][3].
Product Specifications
CAS Number
[5369-00-6]
Target
Reference Standards; Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](C)(C)C.[Cl-]
Molecular Formula
C13H21ClN2O
Molecular Weight
256.77
References & Citations
[1]A Sunami, et al. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A. 2000 Feb 29;97 (5) :2326-31.|[2]Qingmin Chen, et al. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. J Pain. 2004 Jun;5 (5) :281-9.|[3]J A Flatman, et al. Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222. J Neurophysiol. 1982 Aug;48 (2) :419-30.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Curated Selection
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