CGP 20712 (dihydrochloride) (Standard)

CGP 20712 (dihydrochloride) (Standard) is the analytical standard of CGP 20712 (dihydrochloride) . This product is intended for research and analytical applications. CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].

Product Specifications

CAS Number

[1216905-73-5]

UNSPSC

12352005

Target

Adrenergic Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Endocrinology; Neurological Disease

Smiles

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.Cl.Cl

Molecular Formula

C23H27Cl2F3N4O5

Molecular Weight

567.39

References & Citations

[1]Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116 (1) :1635-43.|[2]Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130 (1-2) :137-9.|[3]Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116 (1) :1635-43.