QX-314
QX-314 is a membrane-impermeable quaternary Lidocaine (HY-B0185) derivative with sensory-selective blocking effects. QX-314 inhibits acid-induced esophageal hypersensitivity. QX-314 enters jugular ganglion cells via TRPV1 channels, blocks NaV1.8 channels, and thereby inhibits esophageal sensory conduction. QX-314 can alleviate acid-induced esophageal inflammation. QX-314 can be used for the research on gastroesophageal reflux disease (GERD) [1].
Product Specifications
CAS Number
[21306-56-9]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Sodium Channel; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC
Molecular Formula
C16H27N2O
Molecular Weight
263.40
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101350A/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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