RS 17053 hydrochloride (Standard)
RS 17053 hydrochloride (Standard) is the analytical standard of RS 17053 hydrochloride. This product is intended for research and analytical applications. RS 17053 hydrochloride is a potent and selective α1A adrenoceptor antagonist, with a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.
Product Specifications
CAS Number
169505-93-5
Target
Adrenergic Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Metabolic Disease; Endocrinology
Smiles
[H]Cl.ClC1=CC2=C(NC=C2CC(C)(C)NCCOC3=CC=CC=C3OCC4CC4)C=C1
Molecular Formula
C24H30Cl2N2O2
Molecular Weight
449.41
References & Citations
[1]Ford AP, et al. RS-17053 (N-[2- (2-cyclopropylmethoxyphenoxy) ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for functional alpha 1-adrenoceptors in human prostate: implications for adrenoceptor classification. Mol Pharmacol. 1996 Feb;49 (2) :209-15.|[2]Wellman PJ, et al. Effects of the alpha 1a-adrenoceptor antagonist RS-17053 on phenylpropanolamine-induced anorexia in rats. Pharmacol Biochem Behav. 1997 May-Jun;57 (1-2) :281-4.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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