Veliparib (dihydrochloride) (Standard)

Veliparib (dihydrochloride) (Standard) is the analytical standard of Veliparib (dihydrochloride) (HY-10130) . This product is intended for research and analytical applications. Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.

Product Specifications

CAS Number

[912445-05-7]

Target

Autophagy; PARP; Reference Standards

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Cancer

Smiles

O=C(C1=C2NC([C@@]3(NCCC3)C)=NC2=CC=C1)N.Cl.Cl

Molecular Formula

C13H18Cl2N4O

Molecular Weight

317.21

References & Citations

[1]Donawho CK, et al. ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13 (9) :2728-37.|[2]Penning TD, et al. Discovery of the Poly (ADP-ribose) polymerase (PARP) inhibitor 2-[ (R) -2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52 (2) :514-23.|[3]Albert JM, et al. Inhibition of poly (ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res. 2007 May 15;13 (10) :3033-42.|[4]Robert J. Kinders, et al. Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts. Clin Cancer Res. Author manuscript; available in PMC 2009 Nov 1.