BNTX (maleate)

BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the Kis of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity[1][2].

Product Specifications

CAS Number

[864461-31-4]

Product Name Alternative

7-Benzylidenenaltrexone (maleate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.2

Smiles

O[C@@]1(C/C2=C\C3=CC=CC=C3)[C@]4([C@@](C2=O)([H])OC5=C6O)C5=C(C=C6)C[C@@]1([H])N(CC7CC7)CC4.OC(/C=C\C(O)=O)=O

Molecular Formula

C31H31NO8

Molecular Weight

545.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Portoghese PS, et al. A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone. Eur J Pharmacol. 1992;218 (1) :195-196. |[2]House RV, et al. Suppression of immune function by non-peptidic delta opioid receptor antagonists. Neurosci Lett. 1995 Sep 29;198 (2) :119-22.|[3]Miyata Y, et al. Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi. Bioorg Med Chem Lett. 2011 Aug 15;21 (16) :4710-2.