Veliparib (Standard)

Veliparib (Standard) is the analytical standard of Veliparib. This product is intended for research and analytical applications. Veliparib (ABT-888) is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively[1].

Product Specifications

CAS Number

[912444-00-9]

Product Name Alternative

ABT-888 (Standard)

UNSPSC

12352005

Target

Autophagy; PARP; Reference Standards

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Cancer

Smiles

O=C(C1=C2NC([C@@]3(NCCC3)C)=NC2=CC=C1)N

Molecular Formula

C13H16N4O

Molecular Weight

244.30

References & Citations

[1]Donawho CK, et al. ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13 (9) :2728-37.|[2]Du Y, et al. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 Feb;22 (2) :194-201.|[3]Liu F, et al. Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo. PeerJ. 2016 Apr 4;4:e1890.