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Dihydrexidine (hydrochloride) (Standard)

Dihydrexidine (hydrochloride) (Standard) is the analytical standard of Dihydrexidine (hydrochloride). This product is intended for research and analytical applications. Dihydrexidine hydrochloride (DAR-0100 hydrochloride) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist, with an IC50 of 10 nM for D1 receptor. Dihydrexidine hydrochloride exhibits potent antiparkinsonian activity[1][2][3][4]. Dihydrexidine hydrochloride can stimulate YAP phosphorylation[5].

Product Specifications

CAS Number

137417-08-4

Target

Dopamine Receptor; Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC1=C(O)C=C(CC[C@]2([H])[C@]3([H])C4=C(C=CC=C4)CN2)C3=C1.Cl

Molecular Formula

C17H18ClNO2

Molecular Weight

303.78

References & Citations

[1]Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166 (1) :111-3.|[2]Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262 (1) :383-93.|[3]Salmi P, et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10 (3) :230-42.|[4]Gleason, S. D., et al. Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine. Psychopharmacology, 2006;186 (1), 25–31.|[5]Yu FX, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012;150 (4) :780-791.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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