PD-166866 (Standard)
PD-166866 (Standard) is the analytical standard of PD-166866. This product is intended for research and analytical applications. PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.
Product Specifications
CAS Number
192705-79-6
Target
Autophagy; FGFR; Reference Standards
Related Pathways
Autophagy; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3
Molecular Formula
C20H24N6O3
Molecular Weight
396.44
References & Citations
[1]Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286 (1) :569-77.|[2]Thompson AM, Connolly CJ, Hamby JM, et al. 3- (3,5-Dimethoxyphenyl) -1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. J Med Chem. 2000;43 (22) :4200-4211.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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