PD-166866 (Standard)

PD-166866 (Standard) is the analytical standard of PD-166866 (HY-101296) . This product is intended for research and analytical applications. PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM.

Product Specifications

CAS Number

[192705-79-6]

Target

Autophagy; FGFR; Reference Standards

Related Pathways

Autophagy; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3

Molecular Formula

C20H24N6O3

Molecular Weight

396.44

References & Citations

[1]Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286 (1) :569-77.|[2]Thompson AM, Connolly CJ, Hamby JM, et al. 3- (3,5-Dimethoxyphenyl) -1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. J Med Chem. 2000;43 (22) :4200-4211.