Iberdomide (Standard)

Iberdomide (Standard) is the analytical standard of Iberdomide. This product is intended for research and analytical applications. Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities[1][2].

Product Specifications

CAS Number

[1323403-33-3]

Product Name Alternative

CC-220 (Standard)

UNSPSC

12352005

Target

Apoptosis; Ligands for E3 Ligase; Molecular Glues; Reference Standards

Related Pathways

Apoptosis; Others; PROTAC

Field of Research

Inflammation/Immunology; Cancer

Smiles

O=C([C@@H](N(CC1=C2C=CC=C1OCC3=CC=C(CN4CCOCC4)C=C3)C2=O)CC5)NC5=O

Molecular Formula

C25H27N3O5

Molecular Weight

449.50

References & Citations

[1]Chad C Bjorklund, et al. Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN. Leukemia. 2020 Apr;34 (4) :1197-1201.|[2]Erin W Meermeier, et al. Tumor burden limits bispecific antibody efficacy through T cell exhaustion averted by concurrent cytotoxic therapy. Blood Cancer Discov. 2021 Jul;2 (4) :354-369.