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BMT-090605 (hydrochloride) (Standard)

BMT-090605 (hydrochloride) (Standard) is the analytical standard of BMT-090605 (hydrochloride) (HY-101290A) . This product is intended for research and analytical applications. BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1].

Product Specifications

CAS Number

[2231664-45-0]

Target

AAK1; Cyclin G-associated Kinase (GAK) ; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

N#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O.[H]Cl

Molecular Formula

C21H25ClN4O2

Molecular Weight

400.90

References & Citations

[1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :371-86.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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